Fetuin-A, Valve Calcification, and Diabetes
نویسندگان
چکیده
منابع مشابه
Fetuin-A, Valve Calcification, and Diabetes
In the current issue of Circulation, Ix et al demonstrate an inverse correlation between mitral and aortic valve calcification and serum fetuin-A levels in a cross-sectional study of 970 patients with coronary artery disease and without renal disease.1 Increased serum fetuin was significantly associated with diabetes mellitus, hypertriglyceridemia, serum albumin, and body mass index, with a wea...
متن کاملAssociation of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients.
AIMS Fetuin-A has been identified as a potent circulating inhibitor of ectopic calcification. We investigated the relationship between baseline fetuin-A serum levels and the rate of progression of aortic valve calcification (AVC) in non-dialyzed patients with aortic valve disease (AVD). METHODS AND RESULTS Seventy-seven patients (mean age 70 +/- 8 years) with echocardiographically proven AVD ...
متن کاملAssociation of mitral annular calcification with fetuin-A levels
We read the article, entitled “Association of mitral annular calcification with endothelial dysfunction, carotid intima-media thickness, and serum fetuin-A: An observational study,” by Ziyrek et al. (1) in Anatolian J Cardiol 2013; 13: 752-8, in which they reported that their findings might reflect a close association between mitral annular calcification and cardiovascular risk factors in patie...
متن کاملFetuin-A protects against atherosclerotic calcification in CKD.
Reduced serum levels of the calcification inhibitor fetuin-A associate with increased cardiovascular mortality in dialysis patients. Fetuin-A-deficient mice display calcification of various tissues but notably not of the vasculature. This absence of vascular calcification may result from the protection of an intact endothelium, which becomes severely compromised in the setting of atherosclerosi...
متن کاملThe Role of Fetuin-A in Diabetes and Obesity: The Mechanism and Action
Fetuin-A is a phosphorylated glycoprotein produced by liver.It by binding to calcium ion inhibits ectopic calcium deposition and protects vascular calcification. Fetuin-A acts as a multifactorial protein and its role has been documented from brain development to bone remodeling and immune function, regulation of insulin activity, hepatocyte growth factor activity and inhibition lymphocyte blast...
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ژورنال
عنوان ژورنال: Circulation
سال: 2007
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.107.698324